Pyrido[3,4-d]pyrimidin-4(3H)-one metabolism mediated by aldehyde oxidase is blocked by C2-substitution

1. We have previously described C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-one derivatives as cell permeable inhibitors of the KDM4 and KDM5 subfamilies of JmjC histone lysine demethylases. 2. Although exemplar compound 1 exhibited moderate clearance in mouse liver microsomes, it was highly cleared...

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Detalles Bibliográficos
Autores principales: Hayes, Angela, Mok, N. Yi, Liu, Manjuan, Thai, Ching, Henley, Alan T., Atrash, Butrus, Lanigan, Rachel M., Sejberg, Jimmy, Le Bihan, Yann-Vaï, Bavetsias, Vassilios, Blagg, Julian, Raynaud, Florence I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
General Xenobiochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526139/
https://www.ncbi.nlm.nih.gov/pubmed/27618572
http://dx.doi.org/10.1080/00498254.2016.1230245

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526139/
https://www.ncbi.nlm.nih.gov/pubmed/27618572
http://dx.doi.org/10.1080/00498254.2016.1230245

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