Targeted designed variants of alpha-2-macroglobulin (A2M) attenuate cartilage degeneration in a rat model of osteoarthritis induced by anterior cruciate ligament transection

BACKGROUND: The study was performed to evaluate whether targeted alpha-2-macroglobulin (A2M) variants have a similar or enhanced function at wild-type (wt)-A2M to attenuate cartilage degeneration in vivo. METHODS: In and ex-vivo experiment, bovine cartilage explants (BCE) were incubated with TNF-α a...

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Detalles Bibliográficos
Autores principales: Zhang, Yang, Wei, Xiaochun, Browning, Shawn, Scuderi, Gaetano, Hanna, Lewis S., Wei, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526282/
https://www.ncbi.nlm.nih.gov/pubmed/28743292
http://dx.doi.org/10.1186/s13075-017-1363-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526282/
https://www.ncbi.nlm.nih.gov/pubmed/28743292
http://dx.doi.org/10.1186/s13075-017-1363-4

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