R-spondin2, a novel target of NOBOX: identification of variants in a cohort of women with primary ovarian insufficiency

BACKGROUND: R-spondin2 (Rspo2) is a secreted agonist of the canonical Wnt/β-catenin signaling pathway. Rspo2 plays a key role in development of limbs, lungs and hair follicles, and more recently during ovarian follicle development. Rspo2 heterozygous deficient female mice become infertile around 4 m...

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Detalles Bibliográficos
Autores principales: Bouilly, Justine, Beau, Isabelle, Barraud, Sara, Bernard, Valérie, Delemer, Brigitte, Young, Jacques, Binart, Nadine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526297/
https://www.ncbi.nlm.nih.gov/pubmed/28743298
http://dx.doi.org/10.1186/s13048-017-0345-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526297/
https://www.ncbi.nlm.nih.gov/pubmed/28743298
http://dx.doi.org/10.1186/s13048-017-0345-0

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