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The Mitochondrial Unfolded Protein Response as a Non-Oncogene Addiction to Support Adaptation to Stress during Transformation in Cancer and Beyond
Upon accumulation of misfolded proteins in the mitochondria, the mitochondrial unfolded protein response (UPR(mt)) is activated. This review focuses on the role of this response in cancer. We discuss evidence that during transformation, the UPR(mt) may play an essential role in the maintenance of th...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526845/ https://www.ncbi.nlm.nih.gov/pubmed/28798902 http://dx.doi.org/10.3389/fonc.2017.00159 |