The Mitochondrial Unfolded Protein Response as a Non-Oncogene Addiction to Support Adaptation to Stress during Transformation in Cancer and Beyond

Upon accumulation of misfolded proteins in the mitochondria, the mitochondrial unfolded protein response (UPR(mt)) is activated. This review focuses on the role of this response in cancer. We discuss evidence that during transformation, the UPR(mt) may play an essential role in the maintenance of th...

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Detalles Bibliográficos
Autores principales: Kenny, Timothy C., Manfredi, Giovanni, Germain, Doris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526845/
https://www.ncbi.nlm.nih.gov/pubmed/28798902
http://dx.doi.org/10.3389/fonc.2017.00159
Descripción
Sumario:Upon accumulation of misfolded proteins in the mitochondria, the mitochondrial unfolded protein response (UPR(mt)) is activated. This review focuses on the role of this response in cancer. We discuss evidence that during transformation, the UPR(mt) may play an essential role in the maintenance of the integrity of the mitochondria in the face of increased oxidative stress. However, the role of the UPR(mt) in other diseases is also emerging and is therefore also briefly discussed.

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