The Mitochondrial Unfolded Protein Response as a Non-Oncogene Addiction to Support Adaptation to Stress during Transformation in Cancer and Beyond

Upon accumulation of misfolded proteins in the mitochondria, the mitochondrial unfolded protein response (UPR(mt)) is activated. This review focuses on the role of this response in cancer. We discuss evidence that during transformation, the UPR(mt) may play an essential role in the maintenance of th...

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Autores principales: Kenny, Timothy C., Manfredi, Giovanni, Germain, Doris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526845/
https://www.ncbi.nlm.nih.gov/pubmed/28798902
http://dx.doi.org/10.3389/fonc.2017.00159
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author Kenny, Timothy C.
Manfredi, Giovanni
Germain, Doris
author_facet Kenny, Timothy C.
Manfredi, Giovanni
Germain, Doris
author_sort Kenny, Timothy C.
collection PubMed
description Upon accumulation of misfolded proteins in the mitochondria, the mitochondrial unfolded protein response (UPR(mt)) is activated. This review focuses on the role of this response in cancer. We discuss evidence that during transformation, the UPR(mt) may play an essential role in the maintenance of the integrity of the mitochondria in the face of increased oxidative stress. However, the role of the UPR(mt) in other diseases is also emerging and is therefore also briefly discussed.
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spelling pubmed-55268452017-08-10 The Mitochondrial Unfolded Protein Response as a Non-Oncogene Addiction to Support Adaptation to Stress during Transformation in Cancer and Beyond Kenny, Timothy C. Manfredi, Giovanni Germain, Doris Front Oncol Oncology Upon accumulation of misfolded proteins in the mitochondria, the mitochondrial unfolded protein response (UPR(mt)) is activated. This review focuses on the role of this response in cancer. We discuss evidence that during transformation, the UPR(mt) may play an essential role in the maintenance of the integrity of the mitochondria in the face of increased oxidative stress. However, the role of the UPR(mt) in other diseases is also emerging and is therefore also briefly discussed. Frontiers Media S.A. 2017-07-26 /pmc/articles/PMC5526845/ /pubmed/28798902 http://dx.doi.org/10.3389/fonc.2017.00159 Text en Copyright © 2017 Kenny, Manfredi and Germain. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Kenny, Timothy C.
Manfredi, Giovanni
Germain, Doris
The Mitochondrial Unfolded Protein Response as a Non-Oncogene Addiction to Support Adaptation to Stress during Transformation in Cancer and Beyond
title The Mitochondrial Unfolded Protein Response as a Non-Oncogene Addiction to Support Adaptation to Stress during Transformation in Cancer and Beyond
title_full The Mitochondrial Unfolded Protein Response as a Non-Oncogene Addiction to Support Adaptation to Stress during Transformation in Cancer and Beyond
title_fullStr The Mitochondrial Unfolded Protein Response as a Non-Oncogene Addiction to Support Adaptation to Stress during Transformation in Cancer and Beyond
title_full_unstemmed The Mitochondrial Unfolded Protein Response as a Non-Oncogene Addiction to Support Adaptation to Stress during Transformation in Cancer and Beyond
title_short The Mitochondrial Unfolded Protein Response as a Non-Oncogene Addiction to Support Adaptation to Stress during Transformation in Cancer and Beyond
title_sort mitochondrial unfolded protein response as a non-oncogene addiction to support adaptation to stress during transformation in cancer and beyond
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526845/
https://www.ncbi.nlm.nih.gov/pubmed/28798902
http://dx.doi.org/10.3389/fonc.2017.00159
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