An all-in-one UniSam vector system for efficient gene activation

We have generated a drug-free, all-in-one dCAS9-SAM vector that can activate endogenous gene expression with the potential to modify cell fate. We demonstrate that this strategy can be used in a number of cell lines and avoids exceptionally high levels of gene expression that are observed in standar...

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Detalles Bibliográficos
Autores principales: Fidanza, Antonella, Lopez-Yrigoyen, Martha, Romanò, Nicola, Jones, Rhiannon, Taylor, A. Helen, Forrester, Lesley M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526871/
https://www.ncbi.nlm.nih.gov/pubmed/28743878
http://dx.doi.org/10.1038/s41598-017-06468-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526871/
https://www.ncbi.nlm.nih.gov/pubmed/28743878
http://dx.doi.org/10.1038/s41598-017-06468-6

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