Covalent, Non-Covalent, Encapsulated Nanodrug Regulate the Fate of Intra- and Extracellular Trafficking: Impact on Cancer and Normal Cells

Drugs need to be designed to access the designated intracellular organelle compartments in order to maximize anticancer efficacy. This study identified that covalently conjugated, non-covalent polyethylene glycol coated and encapsulated nanodrugs selectively influence drug uptake, the intracellular...

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Autores principales: Kim, Sang-Woo, Lee, Yeon Kyung, Kim, Sang-Hyun, Park, Jun-Young, Lee, Dong Un, Choi, Jungil, Hong, Jeong Hee, Kim, Sanghyo, Khang, Dongwoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526881/
https://www.ncbi.nlm.nih.gov/pubmed/28743942
http://dx.doi.org/10.1038/s41598-017-06796-7
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author Kim, Sang-Woo
Lee, Yeon Kyung
Kim, Sang-Hyun
Park, Jun-Young
Lee, Dong Un
Choi, Jungil
Hong, Jeong Hee
Kim, Sanghyo
Khang, Dongwoo
author_facet Kim, Sang-Woo
Lee, Yeon Kyung
Kim, Sang-Hyun
Park, Jun-Young
Lee, Dong Un
Choi, Jungil
Hong, Jeong Hee
Kim, Sanghyo
Khang, Dongwoo
author_sort Kim, Sang-Woo
collection PubMed
description Drugs need to be designed to access the designated intracellular organelle compartments in order to maximize anticancer efficacy. This study identified that covalently conjugated, non-covalent polyethylene glycol coated and encapsulated nanodrugs selectively influence drug uptake, the intracellular and extracellular trafficking of cancer cells. The types of nano conjugation modulated intracellular dynamics associated with differential impact on anti-cancer efficacy, but also induced differential cytotoxicity on cancer versus normal cells. In conclusion, this study demonstrated the importance of selecting the appropriate type of nano-conjugation for delivering organelle specific, active chemotherapeutic agents through controlled intracellular trafficking.
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spelling pubmed-55268812017-08-02 Covalent, Non-Covalent, Encapsulated Nanodrug Regulate the Fate of Intra- and Extracellular Trafficking: Impact on Cancer and Normal Cells Kim, Sang-Woo Lee, Yeon Kyung Kim, Sang-Hyun Park, Jun-Young Lee, Dong Un Choi, Jungil Hong, Jeong Hee Kim, Sanghyo Khang, Dongwoo Sci Rep Article Drugs need to be designed to access the designated intracellular organelle compartments in order to maximize anticancer efficacy. This study identified that covalently conjugated, non-covalent polyethylene glycol coated and encapsulated nanodrugs selectively influence drug uptake, the intracellular and extracellular trafficking of cancer cells. The types of nano conjugation modulated intracellular dynamics associated with differential impact on anti-cancer efficacy, but also induced differential cytotoxicity on cancer versus normal cells. In conclusion, this study demonstrated the importance of selecting the appropriate type of nano-conjugation for delivering organelle specific, active chemotherapeutic agents through controlled intracellular trafficking. Nature Publishing Group UK 2017-07-25 /pmc/articles/PMC5526881/ /pubmed/28743942 http://dx.doi.org/10.1038/s41598-017-06796-7 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kim, Sang-Woo
Lee, Yeon Kyung
Kim, Sang-Hyun
Park, Jun-Young
Lee, Dong Un
Choi, Jungil
Hong, Jeong Hee
Kim, Sanghyo
Khang, Dongwoo
Covalent, Non-Covalent, Encapsulated Nanodrug Regulate the Fate of Intra- and Extracellular Trafficking: Impact on Cancer and Normal Cells
title Covalent, Non-Covalent, Encapsulated Nanodrug Regulate the Fate of Intra- and Extracellular Trafficking: Impact on Cancer and Normal Cells
title_full Covalent, Non-Covalent, Encapsulated Nanodrug Regulate the Fate of Intra- and Extracellular Trafficking: Impact on Cancer and Normal Cells
title_fullStr Covalent, Non-Covalent, Encapsulated Nanodrug Regulate the Fate of Intra- and Extracellular Trafficking: Impact on Cancer and Normal Cells
title_full_unstemmed Covalent, Non-Covalent, Encapsulated Nanodrug Regulate the Fate of Intra- and Extracellular Trafficking: Impact on Cancer and Normal Cells
title_short Covalent, Non-Covalent, Encapsulated Nanodrug Regulate the Fate of Intra- and Extracellular Trafficking: Impact on Cancer and Normal Cells
title_sort covalent, non-covalent, encapsulated nanodrug regulate the fate of intra- and extracellular trafficking: impact on cancer and normal cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526881/
https://www.ncbi.nlm.nih.gov/pubmed/28743942
http://dx.doi.org/10.1038/s41598-017-06796-7
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