Lactate oxidation facilitates growth of Mycobacterium tuberculosis in human macrophages

Mycobacterium tuberculosis (Mtb) uses alveolar macrophages as primary host cells during infection. In response to an infection, macrophages switch from pyruvate oxidation to reduction of pyruvate into lactate. Lactate might present an additional carbon substrate for Mtb. Here, we demonstrate that Mt...

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Detalles Bibliográficos
Autores principales: Billig, Sandra, Schneefeld, Marie, Huber, Claudia, Grassl, Guntram A., Eisenreich, Wolfgang, Bange, Franz-Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526930/
https://www.ncbi.nlm.nih.gov/pubmed/28744015
http://dx.doi.org/10.1038/s41598-017-05916-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526930/
https://www.ncbi.nlm.nih.gov/pubmed/28744015
http://dx.doi.org/10.1038/s41598-017-05916-7

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