The Role of N-Acetyl Transferases on Isoniazid Resistance from Mycobacterium tuberculosis and Human: An In Silico Approach

BACKGROUND: N-acetyl transferase (NAT) inactivates the pro-drug isoniazid (INH) to N-acetyl INH through a process of acetylation, and confers low-level resistance to INH in Mycobacterium tuberculosis (MTB). Similar to NAT of MTB, NAT2 in humans performs the same function of acetylation. Rapid acetyl...

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Detalles Bibliográficos
Autores principales: Unissa, Ameeruddin Nusrath, Sukumar, Swathi, Hanna, Luke Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Tuberculosis and Respiratory Diseases 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526952/
https://www.ncbi.nlm.nih.gov/pubmed/28747958
http://dx.doi.org/10.4046/trd.2017.80.3.255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526952/
https://www.ncbi.nlm.nih.gov/pubmed/28747958
http://dx.doi.org/10.4046/trd.2017.80.3.255

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