Early synaptic dysfunction induced by α-synuclein in a rat model of Parkinson’s disease

Evidence suggests that synapses are affected first in Parkinson’s disease (PD). Here, we tested the claim that pathological accumulation of α-synuclein, and subsequent synaptic disruption, occur in absence of dopaminergic neuron loss in PD. We determined early synaptic changes in rats that overexpre...

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Detalles Bibliográficos
Autores principales: Phan, Jenny-Ann, Stokholm, Kathrine, Zareba-Paslawska, Justyna, Jakobsen, Steen, Vang, Kim, Gjedde, Albert, Landau, Anne M., Romero-Ramos, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526979/
https://www.ncbi.nlm.nih.gov/pubmed/28743955
http://dx.doi.org/10.1038/s41598-017-06724-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526979/
https://www.ncbi.nlm.nih.gov/pubmed/28743955
http://dx.doi.org/10.1038/s41598-017-06724-9

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