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Transformation-induced changes in the DNA-nuclear matrix interface, revealed by high-throughput analysis of DNA halos

In higher eukaryotic nuclei, DNA is periodically anchored to an extraction-resistant protein structure, via matrix attachment regions. We describe a refined and accessible method to non-subjectively, rapidly and reproducibly measure both size and stability of the intervening chromatin loops, and use...

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Detalles Bibliográficos
Autores principales: Wilson, Rosemary H. C., Coverley, Dawn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526987/
https://www.ncbi.nlm.nih.gov/pubmed/28743923
http://dx.doi.org/10.1038/s41598-017-06459-7