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Transformation-induced changes in the DNA-nuclear matrix interface, revealed by high-throughput analysis of DNA halos
In higher eukaryotic nuclei, DNA is periodically anchored to an extraction-resistant protein structure, via matrix attachment regions. We describe a refined and accessible method to non-subjectively, rapidly and reproducibly measure both size and stability of the intervening chromatin loops, and use...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526987/ https://www.ncbi.nlm.nih.gov/pubmed/28743923 http://dx.doi.org/10.1038/s41598-017-06459-7 |