Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth

Tumor growth relies on efficient DNA repair to mitigate the detrimental impact of DNA damage associated with excessive cell division. Modulating repair factor function, thus, provides a promising strategy to manipulate malignant growth. Here, we identify the ubiquitin-specific protease USP21 as a po...

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Detalles Bibliográficos
Autores principales: Liu, Jinping, Kruswick, Alex, Dang, Hien, Tran, Andy D., Kwon, So Mee, Wang, Xin Wei, Oberdoerffer, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526993/
https://www.ncbi.nlm.nih.gov/pubmed/28743957
http://dx.doi.org/10.1038/s41467-017-00206-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526993/
https://www.ncbi.nlm.nih.gov/pubmed/28743957
http://dx.doi.org/10.1038/s41467-017-00206-2

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