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Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth
Tumor growth relies on efficient DNA repair to mitigate the detrimental impact of DNA damage associated with excessive cell division. Modulating repair factor function, thus, provides a promising strategy to manipulate malignant growth. Here, we identify the ubiquitin-specific protease USP21 as a po...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526993/ https://www.ncbi.nlm.nih.gov/pubmed/28743957 http://dx.doi.org/10.1038/s41467-017-00206-2 |