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Thrombopoiesis is spatially regulated by the bone marrow vasculature
In mammals, megakaryocytes (MKs) in the bone marrow (BM) produce blood platelets, required for hemostasis and thrombosis. MKs originate from hematopoietic stem cells and are thought to migrate from an endosteal niche towards the vascular sinusoids during their maturation. Through imaging of MKs in t...
Autores principales: | Stegner, David, vanEeuwijk, Judith M. M., Angay, Oğuzhan, Gorelashvili, Maximilian G., Semeniak, Daniela, Pinnecker, Jürgen, Schmithausen, Patrick, Meyer, Imke, Friedrich, Mike, Dütting, Sebastian, Brede, Christian, Beilhack, Andreas, Schulze, Harald, Nieswandt, Bernhard, Heinze, Katrin G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527048/ https://www.ncbi.nlm.nih.gov/pubmed/28743899 http://dx.doi.org/10.1038/s41467-017-00201-7 |
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