Inactivation of DNase1L2 and DNase2 in keratinocytes suppresses DNA degradation during epidermal cornification and results in constitutive parakeratosis

The stratum corneum of the epidermis constitutes the mammalian skin barrier to the environment. It is formed by cornification of keratinocytes, a process which involves the removal of nuclear DNA. Here, we investigated the mechanism of cornification-associated DNA degradation by generating mouse mod...

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Detalles Bibliográficos
Autores principales: Fischer, Heinz, Buchberger, Maria, Napirei, Markus, Tschachler, Erwin, Eckhart, Leopold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527052/
https://www.ncbi.nlm.nih.gov/pubmed/28743926
http://dx.doi.org/10.1038/s41598-017-06652-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527052/
https://www.ncbi.nlm.nih.gov/pubmed/28743926
http://dx.doi.org/10.1038/s41598-017-06652-8

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