Sirt1 negatively regulates FcεRI-mediated mast cell activation through AMPK- and PTP1B-dependent processes

Sirt1, a key regulator of metabolism and longevity, has recently been implicated in the regulation of allergic reactions, although the underlying mechanism remains unclear. Here we show that Sirt1 negatively regulates FcεRI-stimulated mast cell activation and anaphylaxis through two mutually regulat...

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Detalles Bibliográficos
Autores principales: Li, Xian, Lee, Youn Ju, Jin, Fansi, Park, Young Na, Deng, Yifeng, Kang, Youra, Yang, Ju Hye, Chang, Jae-Hoon, Kim, Dong-Young, Kim, Jung-Ae, Chang, Young-Chae, Ko, Hyun-Jeong, Kim, Cheorl-Ho, Murakami, Makoto, Chang, Hyeun Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527079/
https://www.ncbi.nlm.nih.gov/pubmed/28744004
http://dx.doi.org/10.1038/s41598-017-06835-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527079/
https://www.ncbi.nlm.nih.gov/pubmed/28744004
http://dx.doi.org/10.1038/s41598-017-06835-3

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