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Analysis of somatic mutations across the kinome reveals loss-of-function mutations in multiple cancer types
In this study we use somatic cancer mutations to identify important functional residues within sets of related genes. We focus on protein kinases, a superfamily of phosphotransferases that share homologous sequences and structural motifs and have many connections to cancer. We develop several statis...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527104/ https://www.ncbi.nlm.nih.gov/pubmed/28743916 http://dx.doi.org/10.1038/s41598-017-06366-x |