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Cross-validation of optimized composites for preclinical Alzheimer's disease
INTRODUCTION: We discuss optimization and validation of composite end points for presymptomatic Alzheimer's disease clinical trials. Optimized composites offer hope of substantial gains in statistical power or reduction in sample size. But there is tradeoff between optimization and face validit...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527287/ https://www.ncbi.nlm.nih.gov/pubmed/28758145 http://dx.doi.org/10.1016/j.trci.2016.12.001 |