Dysregulation of the miR‐194–CUL4B negative feedback loop drives tumorigenesis in non‐small‐cell lung carcinoma

Cullin 4B (CUL4B), a scaffold protein that assembles CRL4B ubiquitin ligase complexes, is overexpressed in many types of cancers and represses many tumor suppressors through epigenetic mechanisms. However, the mechanisms by which CUL4B is upregulated remain to be elucidated. Here, we show that CUL4B...

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Detalles Bibliográficos
Autores principales: Mi, Jun, Zou, Yongxin, Lin, Xiaohua, Lu, Juanjuan, liu, Xiaochen, Zhao, Hui, Ye, Xiang, Hu, Huili, Jiang, Baichun, Han, Bo, Shao, Changshun, Gong, Yaoqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527444/
https://www.ncbi.nlm.nih.gov/pubmed/28164432
http://dx.doi.org/10.1002/1878-0261.12038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527444/
https://www.ncbi.nlm.nih.gov/pubmed/28164432
http://dx.doi.org/10.1002/1878-0261.12038

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