Histone deacetylase activity mediates acquired resistance towards structurally diverse HSP90 inhibitors

Heat shock protein 90 (HSP90) regulates multiple signalling pathways critical for tumour growth. As such, HSP90 inhibitors have been shown to act as effective anticancer agents in preclinical studies but, for a number of reasons, the same effect has not been observed in the clinical trials to date....

Descripción completa

Detalles Bibliográficos
Autores principales: Chai, Ryan C., Vieusseux, Jessica L., Lang, Benjamin J., Nguyen, Chau H., Kouspou, Michelle M., Britt, Kara L., Price, John T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527463/
https://www.ncbi.nlm.nih.gov/pubmed/28306192
http://dx.doi.org/10.1002/1878-0261.12054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527463/
https://www.ncbi.nlm.nih.gov/pubmed/28306192
http://dx.doi.org/10.1002/1878-0261.12054

Ejemplares similares