Inhibitors of STAT3, β‐catenin, and IGF‐1R sensitize mouse PIK3CA‐mutant breast cancer to PI3K inhibitors

Although mutations in the phosphoinositide 3‐kinase catalytic subunit (PIK3CA) are common in breast cancer, PI3K inhibitors alone have shown modest efficacy. We sought to identify additional pathways altered in PIK3CA‐mutant tumors that might be targeted in combination with PI3K inhibitors. We gener...

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Detalles Bibliográficos
Autores principales: Merino, Vanessa F., Cho, Soonweng, Liang, Xiaohui, Park, Sunju, Jin, Kideok, Chen, Qian, Pan, Duojia, Zahnow, Cynthia A., Rein, Alan R., Sukumar, Saraswati
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527464/
https://www.ncbi.nlm.nih.gov/pubmed/28296140
http://dx.doi.org/10.1002/1878-0261.12053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527464/
https://www.ncbi.nlm.nih.gov/pubmed/28296140
http://dx.doi.org/10.1002/1878-0261.12053

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