A genome‐wide siRNA screen for regulators of tumor suppressor p53 activity in human non‐small cell lung cancer cells identifies components of the RNA splicing machinery as targets for anticancer treatment

Reinstating wild‐type tumor suppressor p53 activity could be a valuable option for the treatment of cancer. To contribute to development of new treatment options for non‐small cell lung cancer (NSCLC), we performed genome‐wide siRNA screens for determinants of p53 activity in NSCLC cells. We identif...

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Detalles Bibliográficos
Autores principales: Siebring‐van Olst, Ellen, Blijlevens, Maxime, de Menezes, Renee X., van der Meulen‐Muileman, Ida H., Smit, Egbert F., van Beusechem, Victor W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527466/
https://www.ncbi.nlm.nih.gov/pubmed/28296343
http://dx.doi.org/10.1002/1878-0261.12052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527466/
https://www.ncbi.nlm.nih.gov/pubmed/28296343
http://dx.doi.org/10.1002/1878-0261.12052

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