Linezolid Dose That Maximizes Sterilizing Effect While Minimizing Toxicity and Resistance Emergence for Tuberculosis

Linezolid has an excellent sterilizing effect in tuberculosis patients but high adverse event rates. The dose that would maximize efficacy and minimize toxicity is unknown. We performed linezolid dose-effect and dose-scheduling studies in the hollow fiber system model of tuberculosis (HFS-TB) for st...

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Detalles Bibliográficos
Autores principales: Srivastava, Shashikant, Magombedze, Gesham, Koeuth, Thearith, Sherman, Carleton, Pasipanodya, Jotam G., Raj, Prithvi, Wakeland, Edward, Deshpande, Devyani, Gumbo, Tawanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527615/
https://www.ncbi.nlm.nih.gov/pubmed/28584143
http://dx.doi.org/10.1128/AAC.00751-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527615/
https://www.ncbi.nlm.nih.gov/pubmed/28584143
http://dx.doi.org/10.1128/AAC.00751-17

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