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Linezolid Dose That Maximizes Sterilizing Effect While Minimizing Toxicity and Resistance Emergence for Tuberculosis
Linezolid has an excellent sterilizing effect in tuberculosis patients but high adverse event rates. The dose that would maximize efficacy and minimize toxicity is unknown. We performed linezolid dose-effect and dose-scheduling studies in the hollow fiber system model of tuberculosis (HFS-TB) for st...
Autores principales: | Srivastava, Shashikant, Magombedze, Gesham, Koeuth, Thearith, Sherman, Carleton, Pasipanodya, Jotam G., Raj, Prithvi, Wakeland, Edward, Deshpande, Devyani, Gumbo, Tawanda |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527615/ https://www.ncbi.nlm.nih.gov/pubmed/28584143 http://dx.doi.org/10.1128/AAC.00751-17 |
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