Pharmacologic inhibition of vacuolar H+ ATPase reduces physiologic and oncogenic Notch signaling

Notch signaling in prominently involved in growth regulation in metazoan tissues. Because of this, Notch is often upregulated in cancer and current efforts point to developing drugs that block its activation. Notch receptor endocytosis towards acidic compartments is a recently appreciated determinan...

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Detalles Bibliográficos
Autores principales: Kobia, Francis, Duchi, Serena, Deflorian, Gianluca, Vaccari, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528540/
https://www.ncbi.nlm.nih.gov/pubmed/24309677
http://dx.doi.org/10.1016/j.molonc.2013.11.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528540/
https://www.ncbi.nlm.nih.gov/pubmed/24309677
http://dx.doi.org/10.1016/j.molonc.2013.11.002

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