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Pharmacologic inhibition of vacuolar H+ ATPase reduces physiologic and oncogenic Notch signaling
Notch signaling in prominently involved in growth regulation in metazoan tissues. Because of this, Notch is often upregulated in cancer and current efforts point to developing drugs that block its activation. Notch receptor endocytosis towards acidic compartments is a recently appreciated determinan...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528540/ https://www.ncbi.nlm.nih.gov/pubmed/24309677 http://dx.doi.org/10.1016/j.molonc.2013.11.002 |