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Evidence that Mediator is essential for Pol II transcription, but is not a required component of the preinitiation complex in vivo
The Mediator complex has been described as a general transcription factor, but it is unclear if it is essential for Pol II transcription and/or is a required component of the preinitiation complex (PIC) in vivo. Here, we show that depletion of individual subunits, even those essential for cell growt...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529107/ https://www.ncbi.nlm.nih.gov/pubmed/28699889 http://dx.doi.org/10.7554/eLife.28447 |