The anti-cancer effects of itraconazole in epithelial ovarian cancer

We assessed the anti-proliferative activity of itraconazole using an EOC cell line (SKOV3ip1) and endothelial cell lines (HUVEC & SVEC4-10). We also examined angiogenesis (VEGFR2, p-ERK, p-PLCr1/2), hedgehog (Gli1, Ptch1, SMO), and mTOR (pS6K1) signaling pathways to determine the mechanism of ac...

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Detalles Bibliográficos
Autores principales: Choi, Chel Hun, Ryu, Ji-Yoon, Cho, Young-Jae, Jeon, Hye-Kyung, Choi, Jung-Joo, Ylaya, Kris, Lee, Yoo-Young, Kim, Tae-Joong, Chung, Joon-Yong, Hewitt, Stephen M., Kim, Byoung-Gie, Bae, Duk-Soo, Lee, Jeong-Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529373/
https://www.ncbi.nlm.nih.gov/pubmed/28747628
http://dx.doi.org/10.1038/s41598-017-06510-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529373/
https://www.ncbi.nlm.nih.gov/pubmed/28747628
http://dx.doi.org/10.1038/s41598-017-06510-7

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