Interplay of Energetics and ER Stress Exacerbates Alzheimer's Amyloid-β (Aβ) Toxicity in Yeast

Alzheimer's disease (AD) is a progressive neurodegeneration. Oligomers of amyloid-β peptides (Aβ) are thought to play a pivotal role in AD pathogenesis, yet the mechanisms involved remain unclear. Two major isoforms of Aβ associated with AD are Aβ40 and Aβ42, the latter being more toxic and pro...

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Detalles Bibliográficos
Autores principales: Chen, Xin, Bisschops, Markus M. M., Agarwal, Nisha R., Ji, Boyang, Shanmugavel, Kumaravel P., Petranovic, Dina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529408/
https://www.ncbi.nlm.nih.gov/pubmed/28798664
http://dx.doi.org/10.3389/fnmol.2017.00232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529408/
https://www.ncbi.nlm.nih.gov/pubmed/28798664
http://dx.doi.org/10.3389/fnmol.2017.00232

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