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Interplay of Energetics and ER Stress Exacerbates Alzheimer's Amyloid-β (Aβ) Toxicity in Yeast

Alzheimer's disease (AD) is a progressive neurodegeneration. Oligomers of amyloid-β peptides (Aβ) are thought to play a pivotal role in AD pathogenesis, yet the mechanisms involved remain unclear. Two major isoforms of Aβ associated with AD are Aβ40 and Aβ42, the latter being more toxic and pro...

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Detalles Bibliográficos
Autores principales:	Chen, Xin, Bisschops, Markus M. M., Agarwal, Nisha R., Ji, Boyang, Shanmugavel, Kumaravel P., Petranovic, Dina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529408/ https://www.ncbi.nlm.nih.gov/pubmed/28798664 http://dx.doi.org/10.3389/fnmol.2017.00232

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