RNA sequencing reveals resistance of TLR4 ligand-activated microglial cells to inflammation mediated by the selective jumonji H3K27 demethylase inhibitor

Persistent microglial activation is associated with the production and secretion of various pro-inflammatory genes, cytokines and chemokines, which may initiate or amplify neurodegenerative diseases. A novel synthetic histone 3 lysine 27 (H3K27) demethylase JMJD3 inhibitor, GSK-J4, was proven to exe...

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Detalles Bibliográficos
Autores principales: Das, Amitabh, Arifuzzaman, Sarder, Yoon, Taeho, Kim, Sun Hwa, Chai, Jin Choul, Lee, Young Seek, Jung, Kyoung Hwa, Chai, Young Gyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529413/
https://www.ncbi.nlm.nih.gov/pubmed/28747667
http://dx.doi.org/10.1038/s41598-017-06914-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529413/
https://www.ncbi.nlm.nih.gov/pubmed/28747667
http://dx.doi.org/10.1038/s41598-017-06914-5

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