Conformational preludes to the latency transition in PAI-1 as determined by atomistic computer simulations and hydrogen/deuterium-exchange mass spectrometry

Both function and dysfunction of serine protease inhibitors (serpins) involve massive conformational change in their tertiary structure but the dynamics facilitating these events remain poorly understood. We have studied the dynamic preludes to conformational change in the serpin plasminogen activat...

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Detalles Bibliográficos
Autores principales: Petersen, Michael, Madsen, Jeppe B., Jørgensen, Thomas J. D., Trelle, Morten B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529462/
https://www.ncbi.nlm.nih.gov/pubmed/28747729
http://dx.doi.org/10.1038/s41598-017-06290-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529462/
https://www.ncbi.nlm.nih.gov/pubmed/28747729
http://dx.doi.org/10.1038/s41598-017-06290-0

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