2-Oxoadenosine induces cytotoxicity through intracellular accumulation of 2-oxo-ATP and depletion of ATP but not via the p38 MAPK pathway

2-Oxoadenosine (2-oxo-Ado), an oxidized form of adenosine, is cytotoxic and induces growth arrest and cell death, which has potential as an anti-cancer drug. However, it is not well understood how 2-oxo-Ado exerts its cytotoxicity. We examined the effects of 2-oxo-Ado on non-tumour cells, namely imm...

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Detalles Bibliográficos
Autores principales: Asada, Shinji, Ohta, Eiko, Akimoto, Yoriko, Abolhassani, Nona, Tsuchimoto, Daisuke, Nakabeppu, Yusaku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529524/
https://www.ncbi.nlm.nih.gov/pubmed/28747712
http://dx.doi.org/10.1038/s41598-017-06636-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529524/
https://www.ncbi.nlm.nih.gov/pubmed/28747712
http://dx.doi.org/10.1038/s41598-017-06636-8

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