Predicting the functional consequences of non-synonymous single nucleotide polymorphisms in IL8 gene

Here we report an in-silico approach for identification, characterization and validation of deleterious non-synonymous SNPs (nsSNPs) in the interleukin-8 gene using three steps. In first step, sequence homology-based genetic analysis of a set of 50 coding SNPs associated with 41 rsIDs using SIFT (So...

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Detalles Bibliográficos
Autores principales: Dakal, Tikam Chand, Kala, Deepak, Dhiman, Gourav, Yadav, Vinod, Krokhotin, Andrey, Dokholyan, Nikolay V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529537/
https://www.ncbi.nlm.nih.gov/pubmed/28747718
http://dx.doi.org/10.1038/s41598-017-06575-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529537/
https://www.ncbi.nlm.nih.gov/pubmed/28747718
http://dx.doi.org/10.1038/s41598-017-06575-4

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