Molecular dynamics simulation analysis of the effect of T790M mutation on epidermal growth factor receptor protein architecture in non-small cell lung carcinoma

Non-small cell lung cancer etiology and its treatment failure are due to epidermal growth factor receptor (EGFR) kinase domain mutations at amino acid position 790. The mutational change from threonine to methionine at position 790 (T790M) is responsible for tyrosine kinase inhibition failure. Using...

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Detalles Bibliográficos
Autores principales: Peng, Xiao-Nu, Wang, Jing, Zhang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530049/
https://www.ncbi.nlm.nih.gov/pubmed/28789446
http://dx.doi.org/10.3892/ol.2017.6387

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530049/
https://www.ncbi.nlm.nih.gov/pubmed/28789446
http://dx.doi.org/10.3892/ol.2017.6387

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