Anticancer metallohelices: nanomolar potency and high selectivity

A range of new helicate-like architectures have been prepared via highly diastereoselective self-assembly using readily accessible starting materials. Six pairs of enantiomers [Fe(2)L(3)]Cl(4)·nH(2)O (L = various bidentate ditopic ligands NN–NN) show very good water solubility and stability. Their a...

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Detalles Bibliográficos
Autores principales: Kaner, Rebecca A., Allison, Simon J., Faulkner, Alan D., Phillips, Roger M., Roper, David I., Shepherd, Samantha L., Simpson, Daniel H., Waterfield, Nicholas R., Scott, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530816/
https://www.ncbi.nlm.nih.gov/pubmed/28808525
http://dx.doi.org/10.1039/c5sc03677a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530816/
https://www.ncbi.nlm.nih.gov/pubmed/28808525
http://dx.doi.org/10.1039/c5sc03677a

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