The status of immunosuppression in patients with stage IIIB or IV non-small-cell lung cancer correlates with the clinical characteristics and response to chemotherapy

BACKGROUND: Indoleamine 2,3-dioxygenase (IDO) catalyzes the rate-limiting step of tryptophan (Trp) degradation via the kynurenine (Kyn) pathway, which inhibits the proliferation of T cells and induces the apoptosis of T cells, leading to immune tolerance. Therefore, IDO has been considered as the mo...

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Detalles Bibliográficos
Autores principales: Wang, Yuan, Hu, Guo-fang, Wang, Zhe-hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530847/
https://www.ncbi.nlm.nih.gov/pubmed/28790848
http://dx.doi.org/10.2147/OTT.S136259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530847/
https://www.ncbi.nlm.nih.gov/pubmed/28790848
http://dx.doi.org/10.2147/OTT.S136259

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