Inhaled AP301 for treatment of pulmonary edema in mechanically ventilated patients with acute respiratory distress syndrome: a phase IIa randomized placebo-controlled trial

BACKGROUND: High-permeability pulmonary edema is a hallmark of acute respiratory distress syndrome (ARDS) and is frequently accompanied by impaired alveolar fluid clearance (AFC). AP301 enhances AFC by activating epithelial sodium channels (ENaCs) on alveolar epithelial cells, and we investigated it...

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Detalles Bibliográficos
Autores principales: Krenn, Katharina, Lucas, Rudolf, Croizé, Adrien, Boehme, Stefan, Klein, Klaus Ulrich, Hermann, Robert, Markstaller, Klaus, Ullrich, Roman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531100/
https://www.ncbi.nlm.nih.gov/pubmed/28750677
http://dx.doi.org/10.1186/s13054-017-1795-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531100/
https://www.ncbi.nlm.nih.gov/pubmed/28750677
http://dx.doi.org/10.1186/s13054-017-1795-x

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