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Inhaled AP301 for treatment of pulmonary edema in mechanically ventilated patients with acute respiratory distress syndrome: a phase IIa randomized placebo-controlled trial
BACKGROUND: High-permeability pulmonary edema is a hallmark of acute respiratory distress syndrome (ARDS) and is frequently accompanied by impaired alveolar fluid clearance (AFC). AP301 enhances AFC by activating epithelial sodium channels (ENaCs) on alveolar epithelial cells, and we investigated it...
Autores principales: | Krenn, Katharina, Lucas, Rudolf, Croizé, Adrien, Boehme, Stefan, Klein, Klaus Ulrich, Hermann, Robert, Markstaller, Klaus, Ullrich, Roman |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531100/ https://www.ncbi.nlm.nih.gov/pubmed/28750677 http://dx.doi.org/10.1186/s13054-017-1795-x |
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