Extracellular lipid-free apolipoprotein E inhibits HCV replication and induces ABCG1-dependent cholesterol efflux

OBJECTIVE: The HCV life cycle and the lipid metabolism are inextricably intertwined. In the blood, HCV virions are associated with lipoproteins, forming lipoviroparticles (LVPs), which are the most infectious form of the virus. Apolipoprotein E (apoE), a key LVP component, plays an essential role in...

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Detalles Bibliográficos
Autores principales: Crouchet, Emilie, Lefèvre, Mathieu, Verrier, Eloi R, Oudot, Marine A, Baumert, Thomas F, Schuster, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2017
Materias:
Hepatology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531222/
https://www.ncbi.nlm.nih.gov/pubmed/27609828
http://dx.doi.org/10.1136/gutjnl-2015-311289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531222/
https://www.ncbi.nlm.nih.gov/pubmed/27609828
http://dx.doi.org/10.1136/gutjnl-2015-311289

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