MRE11 stability is regulated by CK2-dependent interaction with R2TP complex

The MRN (MRE11–RAD50–NBS1) complex is essential for repair of DNA double-strand breaks and stalled replication forks. Mutations of the MRN complex subunit MRE11 cause the hereditary cancer-susceptibility disease ataxia-telangiectasia-like disorder (ATLD). Here we show that MRE11 directly interacts w...

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Detalles Bibliográficos
Autores principales: von Morgen, P, Burdova, K, Flower, T G, O'Reilly, N J, Boulton, S J, Smerdon, S J, Macurek, L, Hořejší, Z
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531254/
https://www.ncbi.nlm.nih.gov/pubmed/28436950
http://dx.doi.org/10.1038/onc.2017.99

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531254/
https://www.ncbi.nlm.nih.gov/pubmed/28436950
http://dx.doi.org/10.1038/onc.2017.99

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