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MRE11 stability is regulated by CK2-dependent interaction with R2TP complex

The MRN (MRE11–RAD50–NBS1) complex is essential for repair of DNA double-strand breaks and stalled replication forks. Mutations of the MRN complex subunit MRE11 cause the hereditary cancer-susceptibility disease ataxia-telangiectasia-like disorder (ATLD). Here we show that MRE11 directly interacts w...

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Detalles Bibliográficos
Autores principales:	von Morgen, P, Burdova, K, Flower, T G, O'Reilly, N J, Boulton, S J, Smerdon, S J, Macurek, L, Hořejší, Z
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531254/ https://www.ncbi.nlm.nih.gov/pubmed/28436950 http://dx.doi.org/10.1038/onc.2017.99

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