DNA-PKcs controls calcineurin mediated IL-2 production in T lymphocytes

Loss of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) activity in mammals results in severe combined immuno-deficiency (SCID). This SCID phenotype has been postulated to be due solely to the function of DNA-PKcs in V(D)J recombination, a process critical for lymphocyte maturation. Howeve...

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Detalles Bibliográficos
Autores principales: Kim Wiese, Ara, Schluterman Burdine, Marie, Turnage, Richard H., Tackett, Alan J., Burdine, Lyle J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531461/
https://www.ncbi.nlm.nih.gov/pubmed/28750002
http://dx.doi.org/10.1371/journal.pone.0181608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531461/
https://www.ncbi.nlm.nih.gov/pubmed/28750002
http://dx.doi.org/10.1371/journal.pone.0181608

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