Cargando…

DNA-PKcs controls calcineurin mediated IL-2 production in T lymphocytes

Loss of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) activity in mammals results in severe combined immuno-deficiency (SCID). This SCID phenotype has been postulated to be due solely to the function of DNA-PKcs in V(D)J recombination, a process critical for lymphocyte maturation. Howeve...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim Wiese, Ara, Schluterman Burdine, Marie, Turnage, Richard H., Tackett, Alan J., Burdine, Lyle J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531461/ https://www.ncbi.nlm.nih.gov/pubmed/28750002 http://dx.doi.org/10.1371/journal.pone.0181608

Ejemplares similares

Proteomic Identification of DNA-PK Involvement within the RET Signaling Pathway
por: Burdine, Lyle J., et al.
Publicado: (2015)

DNA-PKcs kinase activity stabilizes the transcription factor Egr1 in activated immune cells
por: Waldrip, Zachary J., et al.
Publicado: (2021)

10399 DNA-PK(cs) Regulates Stability of Egr1 During T Cell Activation
por: Waldrip, Zachary, et al.
Publicado: (2021)

Ipilimumab-induced colonic perforation
por: Burdine, Lyle, et al.
Publicado: (2014)

Development of VRE meningitis due to haematogenous spread while on high-dose daptomycin therapy
por: Sanikommu, Srivani, et al.
Publicado: (2023)

Time- and radiation-dose dependent changes in the plasma proteome after total body irradiation of non-human primates: Implications for biomarker selection
por: Byrum, Stephanie D., et al.
Publicado: (2017)

KU-0060648 inhibits hepatocellular carcinoma cells through DNA-PKcs-dependent and DNA-PKcs-independent mechanisms
por: Chen, Min-Bin, et al.
Publicado: (2016)

Fetal intracranial hemorrhage associated with maternal coagulopathy and vitamin K deficiency after biliary drain placement: A case report and literature review
por: Abu-Rmaileh, Muhammad, et al.
Publicado: (2021)

Involvement of DNA-PKcs in the IL-6 and IL-12 Response to CpG-ODN Is Mediated by Its Interaction with TRAF6 in Dendritic Cells
por: Ma, Chi, et al.
Publicado: (2013)

Unraveling the roles of WRN and DNA-PKcs at telomeres
por: Beattie, Tara L., et al.
Publicado: (2010)

DNA-PKcs participated in hypoxic pulmonary hypertension
por: Liu, Ying-ying, et al.
Publicado: (2022)

Lost in the bloom: DNA-PKcs in green plants
por: Kumar, Koppolu Raja Rajesh
Publicado: (2023)

Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells
por: Jiang, N, et al.
Publicado: (2013)

Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ
por: Chen, Siyu, et al.
Publicado: (2023)

Loss of outer arm dynein components produce specific and separable phenotypes in zebrafish
por: Burdine, R, et al.
Publicado: (2012)

DNA structure-specific priming of ATR activation by DNA-PKcs
por: Vidal-Eychenié, Sophie, et al.
Publicado: (2013)

A Formula to Calculate Standard Liver Volume Using Thoracoabdominal Circumference
por: Shaw, Brian I., et al.
Publicado: (2017)

Phosphoinositide 3-Kinaseγ Controls the Intracellular Localization of CpG to Limit DNA-PKcs-Dependent IL-10 Production in Macrophages
por: Hazeki, Kaoru, et al.
Publicado: (2011)

Targeting DNA-PKcs and telomerase in brain tumour cells
por: Gurung, Resham Lal, et al.
Publicado: (2014)

DNA-PKcs: A Targetable Protumorigenic Protein Kinase
por: Dylgjeri, Emanuela, et al.
Publicado: (2022)

Beyond DNA Repair: DNA-PKcs in Tumor Metastasis, Metabolism and Immunity
por: Yang, Haitang, et al.
Publicado: (2020)

DNA-PKcs: A Multi-Faceted Player in DNA Damage Response
por: Yue, Xiaoqiao, et al.
Publicado: (2020)

Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs
por: Liang, Shikang, et al.
Publicado: (2022)

Adjuvant Transarterial Chemoembolization Following Curative-Intent Hepatectomy Versus Hepatectomy Alone for Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
por: Esagian, Stepan M., et al.
Publicado: (2021)

Enhancing CRISPR deletion via pharmacological delay of DNA-PKcs
por: Bosch-Guiteras, Núria, et al.
Publicado: (2021)

Structural analysis of the basal state of the Artemis:DNA-PKcs complex
por: Watanabe, Go, et al.
Publicado: (2022)

SENP3‐mediated TIP60 deSUMOylation is required for DNA‐PKcs activity and DNA damage repair
por: Han, Yang, et al.
Publicado: (2022)

The leucine rich region of DNA-PKcs contributes to its innate DNA affinity
por: Gupta, Shikha, et al.
Publicado: (2005)

DNA-PKcs PARylation regulates DNA-PK kinase activity in the DNA damage response
por: Han, Yang, et al.
Publicado: (2019)

Vismodegib: First-in-Class Hedgehog Pathway Inhibitor for Metastatic or Locally Advanced Basal Cell Carcinoma
por: Nix, Nancy M., et al.
Publicado: (2014)

Differential sensitivity of bees to urbanization-driven changes in body temperature and water content
por: Burdine, Justin D., et al.
Publicado: (2019)

BRCA1 modulates the autophosphorylation status of DNA-PKcs in S phase of the cell cycle
por: Davis, Anthony J., et al.
Publicado: (2014)

Targeting DNA-PKcs and ATM with miR-101 Sensitizes Tumors to Radiation
por: Yan, Dan, et al.
Publicado: (2010)

Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy
por: Willoughby, Catherine E., et al.
Publicado: (2019)

53BP1 Mediates the Fusion of Mammalian Telomeres Rendered Dysfunctional by DNA-PKcs Loss or Inhibition
por: Rybanska-Spaeder, Ivana, et al.
Publicado: (2014)

PIDD mediates the association of DNA-PKcs and ATR at stalled replication forks to facilitate the ATR signaling pathway
por: Lin, Yu-Fen, et al.
Publicado: (2018)

Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loops
por: Kusumoto-Matsuo, Rika, et al.
Publicado: (2010)

Assessment of DNA-PKcs kinase activity by quantum dot–based microarray
por: Lafont, Florian, et al.
Publicado: (2018)

DNA-PKcs inhibitor increases the sensitivity of gastric cancer cells to radiotherapy
por: Geng, Wei, et al.
Publicado: (2019)

Structure-Specific nuclease activities of Artemis and the Artemis: DNA-PKcs complex
por: Chang, Howard H.Y., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_8nabb604m8tkdkpcrhlbrqnoui