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Prediction of novel target genes and pathways involved in irinotecan-resistant colorectal cancer
BACKGROUND: Acquired drug resistance to the chemotherapeutic drug irinotecan (the active metabolite of which is SN-38) is one of the significant obstacles in the treatment of advanced colorectal cancer (CRC). The molecular mechanism or targets mediating irinotecan resistance are still unclear. It is...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531462/ https://www.ncbi.nlm.nih.gov/pubmed/28749961 http://dx.doi.org/10.1371/journal.pone.0180616 |