Small molecule perturbation of the CAND1-Cullin1-ubiquitin cycle stabilizes p53 and triggers Epstein-Barr virus reactivation

The chemical probe C60 efficiently triggers Epstein-Barr Virus (EBV) reactivation from latency through an unknown mechanism. Here, we identify the Cullin exchange factor CAND1 as a biochemical target of C60. We also identified CAND1 in an shRNA library screen for EBV lytic reactivation. Gene express...

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Detalles Bibliográficos
Autores principales: Tikhmyanova, Nadezhda, Tutton, Steve, Martin, Kayla A., Lu, Fang, Kossenkov, Andrew V., Paparoidamis, Nicholas, Kenney, Shannon, Salvino, Joseph M., Lieberman, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531659/
https://www.ncbi.nlm.nih.gov/pubmed/28715492
http://dx.doi.org/10.1371/journal.ppat.1006517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531659/
https://www.ncbi.nlm.nih.gov/pubmed/28715492
http://dx.doi.org/10.1371/journal.ppat.1006517

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