The phospho–caveolin-1 scaffolding domain dampens force fluctuations in focal adhesions and promotes cancer cell migration

Caveolin-1 (Cav1), a major Src kinase substrate phosphorylated on tyrosine-14 (Y14), contains the highly conserved membrane-proximal caveolin scaffolding domain (CSD; amino acids 82–101). Here we show, using CSD mutants (F92A/V94A) and membrane-permeable CSD-competing peptides, that Src kinase–depen...

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Detalles Bibliográficos
Autores principales: Meng, Fanrui, Saxena, Sandeep, Liu, Youtao, Joshi, Bharat, Wong, Timothy H., Shankar, Jay, Foster, Leonard J., Bernatchez, Pascal, Nabi, Ivan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531735/
https://www.ncbi.nlm.nih.gov/pubmed/28592633
http://dx.doi.org/10.1091/mbc.E17-05-0278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531735/
https://www.ncbi.nlm.nih.gov/pubmed/28592633
http://dx.doi.org/10.1091/mbc.E17-05-0278

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