Cargando…

The phospho–caveolin-1 scaffolding domain dampens force fluctuations in focal adhesions and promotes cancer cell migration

Caveolin-1 (Cav1), a major Src kinase substrate phosphorylated on tyrosine-14 (Y14), contains the highly conserved membrane-proximal caveolin scaffolding domain (CSD; amino acids 82–101). Here we show, using CSD mutants (F92A/V94A) and membrane-permeable CSD-competing peptides, that Src kinase–depen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meng, Fanrui, Saxena, Sandeep, Liu, Youtao, Joshi, Bharat, Wong, Timothy H., Shankar, Jay, Foster, Leonard J., Bernatchez, Pascal, Nabi, Ivan R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531735/ https://www.ncbi.nlm.nih.gov/pubmed/28592633 http://dx.doi.org/10.1091/mbc.E17-05-0278

Ejemplares similares

Concerted regulation of focal adhesion dynamics by galectin-3 and tyrosine-phosphorylated caveolin-1
por: Goetz, Jacky G., et al.
Publicado: (2008)

Caveolin-1 Y14 phosphorylation suppresses tumor growth while promoting invasion
por: Joshi, Bharat, et al.
Publicado: (2019)

Super Resolution Network Analysis Defines the Molecular Architecture of Caveolae and Caveolin-1 Scaffolds
por: Khater, Ismail M., et al.
Publicado: (2018)

Single molecule network analysis identifies structural changes to caveolae and scaffolds due to mutation of the caveolin-1 scaffolding domain
por: Wong, Timothy H., et al.
Publicado: (2021)

Differential Impact of Caveolae and Caveolin-1 Scaffolds on The Membrane Raft Proteome
por: Zheng, Yu Zi, et al.
Publicado: (2011)

Galectin-3– and phospho-caveolin-1–dependent outside-in integrin signaling mediates the EGF motogenic response in mammary cancer cells
por: Boscher, Cecile, et al.
Publicado: (2013)

Galectin-3 Overrides PTRF/Cavin-1 Reduction of PC3 Prostate Cancer Cell Migration
por: Meng, Fanrui, et al.
Publicado: (2015)

Focal adhesion kinase is a phospho-regulated repressor of Rac and proliferation in human endothelial cells
por: Bryant, Patrick W., et al.
Publicado: (2012)

Variable coloration is associated with dampened population fluctuations in noctuid moths
por: Forsman, Anders, et al.
Publicado: (2015)

Matrix metalloproteinase-2, caveolins, focal adhesion kinase and c-Kit in cells of the mouse myocardium
por: Cho, Woo Jung, et al.
Publicado: (2007)

Positive Phospho-Focal Adhesion Kinase in Gastric Cancer Associates With Poor Prognosis After Curative Resection
por: Peng, Ke, et al.
Publicado: (2022)

Super-resolution modularity analysis shows polyhedral caveolin-1 oligomers combine to form scaffolds and caveolae
por: Khater, Ismail M., et al.
Publicado: (2019)

Caveolin-1-Enhanced Motility and Focal Adhesion Turnover Require Tyrosine-14 but Not Accumulation to the Rear in Metastatic Cancer Cells
por: Urra, Hery, et al.
Publicado: (2012)

Mechanotransduction of matrix stiffness in regulation of focal adhesion size and number: reciprocal regulation of caveolin-1 and β1 integrin
por: Yeh, Yi-Chun, et al.
Publicado: (2017)

p38 MAP kinase–dependent phosphorylation of the Gp78 E3 ubiquitin ligase controls ER–mitochondria association and mitochondria motility
por: Li, Lei, et al.
Publicado: (2015)

The Oxidative Stress-Induced Increase in the Membrane Expression of the Water-Permeable Channel Aquaporin-4 in Astrocytes Is Regulated by Caveolin-1 Phosphorylation
por: Bi, Chongshan, et al.
Publicado: (2017)

Caveolin as a potential drug target for cardiovascular protection
por: Sellers, Stephanie L., et al.
Publicado: (2012)

Caveolae and scaffold detection from single molecule localization microscopy data using deep learning
por: Khater, Ismail M., et al.
Publicado: (2019)

The focal adhesion scaffold protein Hic-5 regulates vimentin organization in fibroblasts
por: Vohnoutka, Rishel B., et al.
Publicado: (2019)

DNA Repair Scaffolds Dampen Checkpoint Signaling by Counteracting the Rad9 Adaptor
por: Ohouo, Patrice Y., et al.
Publicado: (2012)

Caveolin-2 associates with intracellular chlamydial inclusions independently of caveolin-1
por: Webley, Wilmore C, et al.
Publicado: (2004)

PKCθ signaling is required for myoblast fusion by regulating the expression of caveolin-3 and β1D integrin upstream focal adhesion kinase
por: Madaro, Luca, et al.
Publicado: (2011)

To dampen demyelination
por: Maxmen, Amy
Publicado: (2010)

Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration
por: Wu, Jui-Chung, et al.
Publicado: (2015)

Evaluating Caveolin Interactions: Do Proteins Interact with the Caveolin Scaffolding Domain through a Widespread Aromatic Residue-Rich Motif?
por: Byrne, Dominic P., et al.
Publicado: (2012)

Structural Characterization of the Caveolin Scaffolding Domain in Association with Cholesterol-Rich Membranes
por: Hoop, Cody L., et al.
Publicado: (2011)

Synthesis of Phospho-Amino Acid Analogues as Tissue Adhesive Cement Additives
por: Spicer, Christopher D., et al.
Publicado: (2020)

Correction: Evaluating Caveolin Interactions: Do Proteins Interact with the Caveolin Scaffolding Domain through a Widespread Aromatic Residue-Rich Motif?
por: Byrne, Dominic P., et al.
Publicado: (2013)

Caveolin-1 Expression and Cavin Stability Regulate Caveolae Dynamics in Adipocyte Lipid Store Fluctuation
por: Briand, Nolwenn, et al.
Publicado: (2014)

Characterization of a Novel Caveolin Modulator That Reduces Vascular Permeability and Ocular Inflammation
por: Bernatchez, Pascal N., et al.
Publicado: (2021)

A Role for Caveolin and the Urokinase Receptor in Integrin-mediated Adhesion and Signaling
por: Wei, Ying, et al.
Publicado: (1999)

Insights into the Utility of the Focal Adhesion Scaffolding Proteins in the Anaerobic Fungus Orpinomyces sp. C1A
por: Calkins, Shelby, et al.
Publicado: (2016)

Caveolin-1 scaffolding domain peptide regulates glucose metabolism in lung fibrosis
por: Gopu, Venkadesaperumal, et al.
Publicado: (2020)

Caveolin-1 scaffolding domain peptide abrogates autophagy dysregulation in pulmonary fibrosis
por: Venkatesan, Shalini, et al.
Publicado: (2022)

Focal Adhesion Kinases in Adhesion Structures and Disease
por: Eleniste, Pierre P., et al.
Publicado: (2012)

Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics
por: Schober, Markus, et al.
Publicado: (2007)

The Focal Adhesion Analysis Server: a web tool for analyzing focal adhesion dynamics
por: Berginski, Matthew E, et al.
Publicado: (2013)

The KDEL receptor signalling cascade targets focal adhesion kinase on focal adhesions and invadopodia
por: Ruggiero, Carmen, et al.
Publicado: (2017)

Caveolin-1 scaffolding domain peptides enhance anti-inflammatory effect of heme oxygenase-1 through interrupting its interact with caveolin-1
por: Weng, Ping, et al.
Publicado: (2017)

Focal adhesions come unstuck
por: Leslie, Mitch
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_ji2jvpp8fcd16trqf40jomludl